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Cat No. | Product Name | Synonyms | Targets |
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T8827 | EMAC10101d | Carbonic Anhydrase | |
compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range. | |||
T0142 | Brinzolamide | AL-4862 | Carbonic Anhydrase |
Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor. | |||
T61982 | Human carbonic anhydrase II-IN-2 | ||
Human carbonic anhydrase II-IN-24 (Compound R-13) is a potent human carbonic anhydrase (hCA) inhibitor. Human carbonic anhydrase II-IN-24 shows K i s of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respective... | |||
T61981 | Human carbonic anhydrase II-IN-1 | ||
Human carbonic anhydrase II-IN-1 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor. Human carbonic anhydrase II-IN-1 shows Kis of 4.4 nM, 9.2 nM, 480.2 nM and 14.7 nM for hCA II, I, IV and IX, re... | |||
T6503 | Fluorometholone Acetate | NSC 47438,Flarex,Eflone,Oxylone acetate | Glucocorticoid Receptor , Carbonic Anhydrase |
Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. | |||
T2134 | Dorzolamide hydrochloride | MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,Dorzolamide HCl | Carbonic Anhydrase |
Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water ... | |||
T63305 | Carbonic anhydrase inhibitor 6 | Carbonic Anhydrase | |
Carbonic anhydrase inhibitor 6 is a potent human carbonic anhydrase (hCA) inhibitor that inhibits hCA IX, hCA II, hCA XII, and hCA I. It is used in the study of diseases caused by abnormalities in carbonic anhydrase. | |||
T67775 | Enpp/Carbonic anhydrase-IN-1 | PDE , Carbonic Anhydrase | |
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectiv... | |||
T67774 | Compound CDy9 | Carbonic Anhydrase | |
Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II. | |||
T0106 | Methazolamide | L584601,CL 8490 | Carbonic Anhydrase |
Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | |||
T80663 | HCAI/II/IV-IN-28 | WAY-638358 | Carbonic Anhydrase |
hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity. | |||
T36758 | CAIX Inhibitor S4 | S4 | Carbonic Anhydrase |
CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM. | |||
T61745 | HCAI/II-IN-6 | Carbonic Anhydrase | |
hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki values of 220, 4.9, 6.5, and >50,000 nM. hCAI/II-IN-6 showed an... | |||
T23782 | Benzolamide | CL-11366,W 1803,CL 11366,CL11366,W-1803 | Carbonic Anhydrase |
Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons. | |||
T73177 | HCAII-IN-9 | Carbonic Anhydrase | |
hCAII-IN-9 is a potent carbonic anhydrase inhibitor that inhibits hCA II, hCA IX, and hCA XII with IC50s of 1.18 μM and 0.17 μM , and 2.99 μM , respectively. hCAII-IN-9 is not blood-brain barrier permeable. | |||
T0267 | Zonisamide | AD 810,CI 912 | Calcium Channel , Sodium Channel , Carbonic Anhydrase |
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms... | |||
T27673 | JNJ-26990990 | Others | |
JNJ-26990990 is a broad-spectrum anticonvulsant drug as a second-generation followup to the marketed drug topiramate. It was designed to have the same anticonvulsant effects as topiramate, but without the side effects as... | |||
T0782 | Benzthiazide | Aquatag,Lemazide,Dihydrex | Carbonic Anhydrase |
Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted ... | |||
T60848 | Carbonic anhydrase inhibitor 3 | ||
Carbonic anhydrase inhibitor 3 (compound 11g) is an inhibitor of carbonic anhydrase II that reduces the intraocular pressure in glaucomatous rabbits [1]. | |||
T61120 | Carbonic anhydrase inhibitor 2 | ||
Compound 7c, identified as carbonic anhydrase inhibitor 1, effectively inhibits carbonic anhydrase II. This inhibitor, also known as carbonic anhydrase inhibitor 3, lowers intraocular pressure in glaucomatous rabbits [1]... | |||
T61980 | Carbonic anhydrase inhibitor 8 | ||
Carbonic anhydrase inhibitor 8 (compound R-13) is a potent human carbonic anhydrase (hCA). Carbonic anhydrase inhibitor 8 shows K i values of 60.7 nM, 320.7 nM, 2298 nM for hCA I, hCA II, hCA IV, respectively. | |||
T61340 | CAII-IN-3 | ||
CAII-IN-3 (compound 3h) is a thiosemicarbazone derivative known for its potent inhibition of carbonic anhydrase-II (CA-II). It exhibits an IC50 value of 13.4 μM [1]. | |||
T78840 | Carbonic anhydrase inhibitor 15 | Carbonic Anhydrase | |
Carbonic Anhydrase Inhibitor 15 (Compound 8), with an inhibitory constant (K_i) of 8.5 nM for hCA II, exhibits analgesic effects [1]. | |||
T61292 | CAII-IN-1 | ||
CAII-IN-1 (compound 3n) is a thiosemicarbazide derivative that acts as a potent and selective inhibitor of carbonic anhydrase-II (CA-II), with an IC50 value of 10.3 μM for bovine CA-II. This compound (CAII-IN-1) finds ut... | |||
T63731 | Carbonic anhydrase inhibitor 9 | ||
Carbonic anhydrase inhibitor 9 is a potent inhibitor of carbonic anhydrase (CA) that acts on hCA II (Ki: 56.4 nM) and IX (Ki: 56.9 nM) and exhibits antiproliferative effects. | |||
T63005 | Carbonic anhydrase inhibitor 11 | ||
Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor that acts on CA II (Ki: 40 nM), CA IX (Ki: 39 nM) and CA XII (Ki: 900 nM). | |||
T62976 | Carbonic anhydrase inhibitor 5 | ||
Carbonic anhydrase inhibitor 5 is a potent and selective inhibitor of human carbonic anhydrase (hCA), acting on hCA II (IC50: 42.9 nM), hCA IX (IC50: 47.6 nM) and hCA XII (IC50: 6.7 nM). | |||
T62666 | Carbonic anhydrase inhibitor 7 | ||
Carbonic anhydrase inhibitor 7 is a potent inhibitor of human carbonic anhydrase (hCA), acting on hCA IX (Ki: 6.5 nM), hCA II (Ki: 7.1 nM), hCA XII (Ki: 72.1 nM) and hCA I (Ki: 255.8 nM). | |||
T63467 | HCAII-IN-5 | ||
hCAII-IN-5 (compound 12h) is a potent, selective inhibitor of human carbonic anhydrase II (hCA II) with an inhibition constant (IC50) of 4.55 µM [1]. | |||
T61842 | Carbonic anhydrase inhibitor 14 | ||
Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibit... | |||
T64241 | Brinzolamide hydrochloride | ||
Brinzolamide (AL-4862) hydrochloride is a selective inhibitor (IC50: 3.2 nM) of carbonic anhydrase II. Brinzolamide hydrochloride inhibits ciliary CA-II and reduces atrial fluid secretion, thereby reducing intraocular pr... | |||
T61974 | CAII-IN-2 | ||
CAII-IN-2 (compound 3g) is a thiosemicarbazide derivative. CAII-IN-2 is a potent, selective carbonic anhydrase-II (CA-II) inhibitor with an IC50 of 12.1 μM for bovine CA-II. CAII-IN-2 has research value in carbonic anhyd... | |||
T83137 | ALP/Carbonic anhydrase-IN-1 | Carbonic Anhydrase | |
Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkaline phosphatase (ALP). It exhibits inhibitory IC50 values of 0.... | |||
T61282 | HCAI/II-IN-2 | ||
hCAI/II-IN-2 (compound 2b) is a highly effective dual inhibitor of human carbonic anhydrase I and II (hCA I/II), with Ki values of 40.97 nM, 15.15 nM, and 61.88 nM for hCA I, hCA II, and hCA IX, respectively. With its an... | |||
T74587 | Phenylsulfamide | ||
Phenylsulfamide (Compound 10), acting as an inhibitor of human carbonic anhydrase-II (hCA-II), exhibits a dissociation constant (Kd) of 45.50 μM and an inhibition constant (Ki) of 79.60 μM [1]. | |||
T62892 | HCAI/II-IN-1 | ||
hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor that acts on hCA I (IC50: 0.047 μM) and hCA II (IC50: 0.024 μM). | |||
T63805 | β-Glucuronidase/hCAII-IN-1 | ||
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50 values of 440.1 μM and 4.91 μM, respectively [1]. | |||
T63557 | HCA I-IN-1 | ||
hCA I-IN-1 is a human carbonic anhydrase I (hCA I) inhibitor that acts on hCA I (Ki: 38.3 nM), hCA II (Ki: 716.4 nM), hCAIX (Ki: 940.1 nM) and hCAXII (Ki: 192.8 nM). | |||
T63753 | HCAIX-IN-3 | ||
hCAII-IN-3 (compound 7e) is a selective and potent carbonic anhydrase (CA II/IX) inhibitors with their Kis values of 124.2 and 30.5 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease. | |||
T61164 | HCAII-IN-3 | ||
hCAII-IN-3 (Compound 16) is an inhibitor of human carbonic anhydrase (hCA). It exhibits high affinity for hCA I, hCA II, hCA IX, and hCA XII, with Ki values of 403.8 nM, 5.1 nM, 10.2 nM, and 5.2 nM, respectively. Notably... | |||
T63908 | HCAII-IN-4 | ||
hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM. Additionally, it demonstrates inhibition of β-glucuronidase, presenting a... | |||
T35713 | N-desethyl Brinzolamide (oxalate) | ||
N-desethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1It inhibits CAII and CAIV activities (IC50s = 1.28 and 128 nM, respectively). 1.Kim, C.-Y., Whittington, D.A., Chang... | |||
T61263 | HCA IX-IN-1 | ||
hCA IX-IN-1 (Compound 6f) is a human carbonic anhydrase ( hCA ) inhibitor with K i values of 331.4, 28.4, 9.4 and 17.8 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-1 shows anticancer activity [1]... | |||
T63972 | HCA I-IN-2 | ||
hCA I-IN-2 (Compound 6d) is a selective inhibitor of human carbonic anhydrase I (hCA I) and acts on hCA I (Ki: 18.8 nM), hCA II (Ki: 375.1 nM), hCAIX (Ki: 1721 nM) and hCAXII (Ki: 283.9 nM). | |||
T62101 | HCAXII-IN-2 | ||
hCAXII-IN-2 (compound 5i) is a potent inhibitor of human carbonic anhydrase XII (hCA XII) (Ki: 84.2 nM) and hCA IX (Ki: 268.5 nM), with low activity against hCA I and hCA II. | |||
T63631 | HCAII-IN-2 | ||
hCAII-IN-2 is a cytoplasmic human carbonic anhydrase (hCA) inhibitor that acts on hCA I (Ki: 261.4 nM), hCA II (Ki: 3.8 nM), hCA IX (Ki: 19.6 nM) and hCA XII (Ki: 45.2 nM). | |||
T63752 | HCAII-IN-1 | ||
hCAII-IN-1 (compound 7f) is a selective and potent inhibitor of carbonic anhydrase (CA II/IX) with their Kis values of 1.2 and 113.6 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease. | |||
T63764 | HCA XII/II/IX-IN-1 | ||
hCA XII/II/IX-IN-1 is a potent inhibitor of human carbonic anhydrase (hCA) and is able to act on hCA I (IC50: 2.6 μM), hCA II (IC50: 0.004 μM), hCA IX (IC50: 0.005 μM) and hCA XII (IC50: 0.001 μM). hCA XII/II/IX -IN-1 ex... | |||
T74331 | HCAII-IN-7 | ||
Compound R-13, also known as hCAII-IN-7, is a powerful inhibitor of human carbonic anhydrase (hCA), exhibiting inhibition constants (Ki) of 60.7 nM for hCA I, 320.7 nM for hCA II, 2298 nM for hCA IV, and 35.2 nM for hCA ... | |||
T72122 | Carbonic anhydrase inhibitor 12 | Carbonic Anhydrase | |
Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and 271 nM for CA I. Moreover, it demonstrates significant anti... |
Cat No. | Product Name | Synonyms | Targets |
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TN2095 | Pomiferin | NOS , NF-κB , PDE | |
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities. |
Cat No. | Product Name | Species | Expression System |
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TMPY-01735 | Carbonic Anhydrase 2 Protein, Human, Recombinant (His) | Human | E. coli |
Carbonic Anhydrase 2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30 kDa and the accession number is P00918. | |||
TMPH-03259 | Carbonic Anhydrase 2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide abso... | |||
TMPJ-00701 | Carbonic Anhydrase 11 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of ... | |||
TMPY-02111 | Carbonic Anhydrase 2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Carbonic Anhydrase 2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30.4 kDa and the accession number is AAH55291.1. |